Investigations on Genetic Architecture of Hairy Loci in Dairy Cattle by Using Single and Whole Genome Regression Approaches

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Karacaoren B.

ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES, cilt.29, sa.7, ss.938-943, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 7
  • Basım Tarihi: 2016
  • Doi Numarası: 10.5713/ajas.15.0640
  • Dergi Adı: ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.938-943
  • Anahtar Kelimeler: Genome Wide Association Analyses, Discordant Sib Pair Analyses, Whole Genome Regression Analyses, ASSOCIATION ANALYSIS, WIDE ASSOCIATION, MIXED-MODEL
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Development of body hair is an important physiological and cellular process that leads to better adaption in tropical environments for dairy cattle. Various studies suggested a major gene and, more recently, associated genes for hairy locus in dairy cattle. Main aim of this study was to i) employ a variant of the discordant sib pair model, in which half sibs from the same sires are randomly sampled using their affection statues, ii) use various single marker regression approaches, and iii) use whole genome regression approaches to dissect genetic architecture of the hairy gene in the cattle. Whole and single genome regression approaches detected strong genomic signals from Chromosome 23. Although there is a major gene effect on hairy phenotype sourced from chromosome 23: whole genome regression approach also suggested polygenic component related with other parts of the genome. Such a result could not be obtained by any of the single marker approaches.