Expression of vascular endothelial growth factor and transforming growth factor alpha in rat testis during chronic renal failure

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Seval-Celik Y., AKKOYUNLU G., Kocamaz E., KÖKSAL İ. T., Ozer S., Baykara M., ...Daha Fazla

FOLIA HISTOCHEMICA ET CYTOBIOLOGICA, cilt.52, sa.4, ss.308-316, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 52 Sayı: 4
  • Basım Tarihi: 2014
  • Doi Numarası: 10.5603/fhc.a2014.0032
  • Dergi Adı: FOLIA HISTOCHEMICA ET CYTOBIOLOGICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.308-316
  • Anahtar Kelimeler: chronic renal failure, peritoneal dialysis, rat, testis, spermatogenesis, TGF-alpha, VEGF, IHC, MALE REPRODUCTIVE FUNCTION, FACTOR RECEPTOR, EGF RECEPTOR, ECTOPLASMIC SPECIALIZATION, SEMINIFEROUS EPITHELIUM, AUTOCRINE REGULATION, GONADAL DYSFUNCTION, NEUROTROPHIC FACTOR, TRANSGENIC MICE, CORD FORMATION
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Introduction. Vascular endothelial growth factor (VEGF) is known to influence testis function. Transforming growth factor alpha (TGF-alpha) is expressed in the postnatal testis, and has been demonstrated to stimulate testis development. Systemic diseases such as chronic renal failure (CRF) interfere with hypothalamic-pituitary-gonadal axis, which may cause defective steroidogenesis and gonadal functions. The aim of this study was to investigate the expression and localization of VEGF and TGF-alpha in testicular tissues of experimental CRF model.