Expression of vascular endothelial growth factor and transforming growth factor alpha in rat testis during chronic renal failure

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Seval-Celik Y., AKKOYUNLU G., Kocamaz E., KÖKSAL İ. T., Ozer S., Baykara M., ...More

FOLIA HISTOCHEMICA ET CYTOBIOLOGICA, vol.52, no.4, pp.308-316, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 52 Issue: 4
  • Publication Date: 2014
  • Doi Number: 10.5603/fhc.a2014.0032
  • Journal Name: FOLIA HISTOCHEMICA ET CYTOBIOLOGICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.308-316
  • Keywords: chronic renal failure, peritoneal dialysis, rat, testis, spermatogenesis, TGF-alpha, VEGF, IHC, MALE REPRODUCTIVE FUNCTION, FACTOR RECEPTOR, EGF RECEPTOR, ECTOPLASMIC SPECIALIZATION, SEMINIFEROUS EPITHELIUM, AUTOCRINE REGULATION, GONADAL DYSFUNCTION, NEUROTROPHIC FACTOR, TRANSGENIC MICE, CORD FORMATION
  • Akdeniz University Affiliated: Yes

Abstract

Introduction. Vascular endothelial growth factor (VEGF) is known to influence testis function. Transforming growth factor alpha (TGF-alpha) is expressed in the postnatal testis, and has been demonstrated to stimulate testis development. Systemic diseases such as chronic renal failure (CRF) interfere with hypothalamic-pituitary-gonadal axis, which may cause defective steroidogenesis and gonadal functions. The aim of this study was to investigate the expression and localization of VEGF and TGF-alpha in testicular tissues of experimental CRF model.