Is the cell death in mesial temporal sclerosis apoptotic?

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Uysal H., CEVIK I., SOYLEMEZOGLU F., ELIBOL B., Gursoy-Ozdemir Y., EVRENKAYA T., ...More

EPILEPSIA, vol.44, no.6, pp.778-784, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 6
  • Publication Date: 2003
  • Doi Number: 10.1046/j.1528-1157.2003.37402.x
  • Journal Name: EPILEPSIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.778-784
  • Keywords: epilepsy, cell death, Bcl-2, Bax, caspases, BAX PROTEIN EXPRESSION, ALZHEIMERS-DISEASE, DNA FRAGMENTATION, CEREBRAL-ISCHEMIA, NEURONAL DEATH, BCL-X, BRAIN, DAMAGE, IMMUNOREACTIVITY, HIPPOCAMPUS
  • Akdeniz University Affiliated: Yes

Abstract

Purpose: Mesial temporal sclerosis (NITS) is characterized by neuronal loss in the hippocampus. Studies on experimental models and patients with intractable epilepsy suggest that apoptosis may be involved in neuronal death induced by recurrent seizures.