Long term results of photodynamic therapy in intraocular tumors

Karaca B. Ö., Türkoğlu E. B., DOĞAN M. E.

Photodiagnosis and Photodynamic Therapy, vol.42, 2023 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 42
  • Publication Date: 2023
  • Doi Number: 10.1016/j.pdpdt.2023.103564
  • Journal Name: Photodiagnosis and Photodynamic Therapy
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Keywords: Intraocular tumors, Choroidal hemangioma, Choroidal osteoma, Choroidal melanoma, Photodynamic therapy
  • Akdeniz University Affiliated: Yes


Purpose: To report long term results of photodynamic therapy (PDT) as treatment for intraocular tumors Methods: Retrospective interventional case series of 15 patients. All patients treated with standard-fluence PDT (83 s; 50 J/cm2) using verteporfin. Outcome measures: Tumor diameter, tumor thickness, subretinal fluid resolution, best-corrected visual acuity,intraocular pressure and PDT complications. Results: 10 patients (66.7% of total patients) were diagnosed with choroidal hemangioma, 3 patients (20% of total patients) were diagnosed with choroidal melanoma, and 2 patients (13,3% of total patients) were diagnosed with choroidal osteoma. Mean follow-up time was 33±18 months. The mean visual acuity was determined as 1.29 ± 0.98 logMAR in the examinations just before the PDT application. At the end of the follow-up period, the mean visual acuity was calculated as 1.41 ± 1.07 logMAR. While VA increased in 3 (20%) patients and decreased in 5 (33.3%) patients; It was determined that VA value did not change after treatment in 7 (46.7%) patients. The mean lesion diameter before PDT was 6573 ± 2115 µm (range; 1500–10,000 µm). The mean tumor thickness before PDT was 3624 ± 1404 µm (range; 600–6000 µm). The mean lesion diameter after treatment was 6026 ± 2521 µm (range; 0–9000 µm), and the mean tumor thickness after treatment was 2280 ± 1740 µm (range; 0–6000 µm).After the PDT, tumor size decreased in 8 (53.3%) patients, increased in 3 (20%) patients, and no change in tumor size was observed in 4 (26.7%) patients. Mean IOP values of all patients were 14.06 ± 3.17 mmHg before treatment; after treatment, it was measured as 13.46 ± 1.70 mmHg. After the treatment, geographic atrophy developed in 1 (6.7%) patient, cystoid macular edema developed in 1 (6.7%) patient, Retinal Pigment Epithelium (RPE) and choroidal atrophy developed in 1 (6.7%) patient. Conclusion: There are not enough cases of each to clearly distinguish between these 3 types of ocular cancers.However PDT may be a good option in the treatment of intraocular tumors with the chance of selective treatment and successful response.