Rho-kinase is a negative regulator of red blood cell eNOS under basal conditions

ÜLKER P., ÖZEN N., Abduleyeva G., KÖKSOY S., YARAŞ N., BASRALI F.

CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, vol.72, no.4, pp.407-419, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 72 Issue: 4
  • Publication Date: 2019
  • Doi Number: 10.3233/ch-190578
  • Journal Name: CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.407-419
  • Keywords: Red blood cells, Rho-kinase, nitric oxide, nitric oxide synthase, NITRIC-OXIDE SYNTHASE, PROTEIN-KINASE, ACTIN CYTOSKELETON, RHOA/RHO-KINASE, INHIBITION, DEFORMABILITY, ACTIVATION, PRESSURE
  • Akdeniz University Affiliated: Yes

Abstract

BACKGROUND: Rho-kinase, an effector of the small GTPase RhoA, is known to be a novel inhibitory regulator of eNOS in endothelial cells under basal conditions and disease states. However, although RBC possesses active RhoA/Rho-kinase pathway, Rho-kinase mediated eNOS regulation has not been investigated in RBC, so far.