Rho-kinase is a negative regulator of red blood cell eNOS under basal conditions

ÜLKER P., ÖZEN N., Abduleyeva G., KÖKSOY S., YARAŞ N., BASRALI F.

CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, cilt.72, sa.4, ss.407-419, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 72 Sayı: 4
  • Basım Tarihi: 2019
  • Doi Numarası: 10.3233/ch-190578
  • Dergi Adı: CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.407-419
  • Anahtar Kelimeler: Red blood cells, Rho-kinase, nitric oxide, nitric oxide synthase, NITRIC-OXIDE SYNTHASE, PROTEIN-KINASE, ACTIN CYTOSKELETON, RHOA/RHO-KINASE, INHIBITION, DEFORMABILITY, ACTIVATION, PRESSURE
  • Akdeniz Üniversitesi Adresli: Evet

Özet

BACKGROUND: Rho-kinase, an effector of the small GTPase RhoA, is known to be a novel inhibitory regulator of eNOS in endothelial cells under basal conditions and disease states. However, although RBC possesses active RhoA/Rho-kinase pathway, Rho-kinase mediated eNOS regulation has not been investigated in RBC, so far.