Behcet's Disease: Current Aspects in the Etiopathogenesis

Akman A., ALPSOY E.

TURKDERM-TURKISH ARCHIVES OF DERMATOLOGY AND VENEROLOGY, vol.43, pp.32-38, 2009 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 43
  • Publication Date: 2009
  • Journal Name: TURKDERM-TURKISH ARCHIVES OF DERMATOLOGY AND VENEROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.32-38
  • Keywords: Behcet's disease, aetiopathogenesis, genetic factors, infectious agents, immunologic system, TURKISH PATIENTS, PERIODONTAL FINDINGS, GENE POLYMORPHISMS, T-CELLS, STRONG ASSOCIATION, CLOSE ASSOCIATION, ENDOTHELIAL-CELLS, JAPANESE PATIENTS, INTERFERON-GAMMA, MIC-A
  • Akdeniz University Affiliated: Yes

Abstract

Behcet's disease (BD) is a chronic, relapsing, systemic vasculitis. The aetiology of BID remains unknown, but the most widely held hypothesis of the disease pathogenesis is that an altered immune response triggered by an infectious agent or by an otoantigen in a genetically susceptible host. In this paper, we aimed to overview the main aetiopathogenetic hypotheses for the disease including genetic factors, infectious agents and immunologic abnormalities. (Turkderm 2009; 43 Suppl 2: 32-8)