The efficiency and safety of N-acetylcysteine augmentation in the autistic children with severe irritability and aggression: six cases

ÖNDER A., Surer Adanir A., GİZLİ ÇOBAN Ö., Bilac O., Kara A.

ANADOLU PSIKIYATRI DERGISI-ANATOLIAN JOURNAL OF PSYCHIATRY, cilt.21, sa.2, ss.218-221, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 2
  • Basım Tarihi: 2020
  • Doi Numarası: 10.5455/apd.53708
  • Dergi Adı: ANADOLU PSIKIYATRI DERGISI-ANATOLIAN JOURNAL OF PSYCHIATRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, Psycinfo, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.218-221
  • Anahtar Kelimeler: autism, irritability, N-Acetylcysteine, aggresion, DOUBLE-BLIND, TRIAL, BEHAVIOR
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Autism spectrum disorder (ASD) is characterized by deficits in social interactions and communication, and restricted and stereotypic behaviors. A growing body of evidence has identified metabolic pathways and glutamatergic neuro-transmission affecting oxidative stress levels as potential targets of drug development in autism spectrum disorders. N-acetylcysteine (NA C) is an antioxidant that modulate glutamate and reduce oxidative stress, both associated with the pathophysiology of ASD. N-acetylcysteine has been identified as a potential treatment agent for irritability and self-injurious behaviors in autism. In this case report, we report six cases of autism with severe symptoms of irritability and aggression, two of them responded well to N-acetylcysteine treatment, two of them responded partially and while two did not.