Frequency of masked hypertension in patients with nonfunctioning adrenal incidentalomas with normal and high normal blood pressure

YILMAZ F., SÖZEL H., Keles M., Yilmaz U.

IRISH JOURNAL OF MEDICAL SCIENCE, cilt.191, sa.4, ss.1631-1638, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 191 Sayı: 4
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1007/s11845-021-02734-9
  • Dergi Adı: IRISH JOURNAL OF MEDICAL SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.1631-1638
  • Anahtar Kelimeler: Ambulatory blood pressure monitoring, Hypertension, Masked hypertension, Non-functioning adrenal incidentaloma, Office blood pressure, CARDIOVASCULAR EVENTS, MANAGEMENT, MORTALITY, SOCIETY, RISK
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Objectives Nonfunctioning adrenal incidentalomas (NFAIs) are associated with increased cardiovascular risk, but the frequency of masked hypertension (MH) is uncertain in these patients. This study aimed to evaluate the prevalence of MH by ambulatory blood pressure monitoring in patients with NFAIs. Methods The study included a total of 85 individuals: 43 patients with NFAIs and 42 controls of similar age, gender, BMI, smoking, and diabetes. The office BP and ABPM parameters of the NFAI and controls were measured. Biochemical, hormonal, and radiological data were obtained retrospectively in the NFAI group. Results There were no statistically significant difference between the NFAI and control groups in relation to the office SBP (134.4 +/- 37.2 mmHg vs 133.1 +/- 35.8 mmHg, p = 0.273) and office DBP (87.4 +/- 14.5 mmHg vs 86.8 +/- 13.7 mmHg, p = 0.318). Besides, normal (28% vs 28.6%, p = 0.176) and high normal blood pressure (72% vs 71.4%, p = 0.332) rates were similar. The prevalence of MH was significantly higher in patients with NFAI than in controls (25.5% vs 9.5%, p = 0.037). MH was significantly associated with diabetes odds ratio (OR) = 2.07, p = 0.044, office SBP (OR = 1.41, p = 0.046), smoking (OR = 1.46, p = 0.031), BMI (OR = 1.17, p = 0.037), and morning cortisol (OR = 1.21, p = 0.039). Conclusion The prevalence of MH in the NFAI patient's was higher than in the control group. Patients with NFAI with high normal blood pressure should be evaluated for MH.