Cutaneous Leukocytoclastic Vasculitis due to Salmonella enteritidis in a Child with Interleukin-12 Receptor Beta-1 Deficiency


Filiz S., Uygun D. F. K., Verhard E. M., van Dissel J. T., Uygun V., Bassorgun C. İ., ...More

PEDIATRIC DERMATOLOGY, vol.31, no.2, pp.236-240, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 2
  • Publication Date: 2014
  • Doi Number: 10.1111/j.1525-1470.2012.01856.x
  • Journal Name: PEDIATRIC DERMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.236-240
  • Akdeniz University Affiliated: Yes

Abstract

Defects in the interleukin 12 (IL-12)/interferon gamma (IFN-) pathway result in Mendelian susceptibility to mycobacterial disease (MSMD). IL-12 receptor beta 1 (IL-12R1) deficiency, the most common form of MSMD, is associated with weakly virulent mycobacteria and salmonella. Infections in patients with this deficiency are extraintestinal, or septicemic, recurrent infections with nontyphoid salmonellae. Here we report a case of an IL-12R1 deficiency with cutaneous leukocytoclastic vasculitis due to Salmonella enteritidis.