The effect of tigecycline and ertapenem against clinical isolates of Brucella melitensis detected by E-test on different media

Tanyel E., Coban A. Y., Fisgin N. T., Tulek N.

INDIAN JOURNAL OF MEDICAL MICROBIOLOGY, cilt.28, sa.4, ss.370-371, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 4
  • Basım Tarihi: 2010
  • Doi Numarası: 10.4103/0255-0857.71822
  • Dergi Adı: INDIAN JOURNAL OF MEDICAL MICROBIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.370-371
  • Anahtar Kelimeler: Brucellosis, tigecycline, ertapenem
  • Akdeniz Üniversitesi Adresli: Hayır

Özet

In this study, in vitro activity of tigecycline (TIG) and ertapenem (ERT) against clinical isolates of Brucella melitensis and the effect of different media on in vitro test results were investigated. The in vitro effects of TIG and ERT to 38 B. melitensis isolates were comparatively investigated in brucella agar and 5% sheep blood agar. MIC value of ERT was 0.032 mu g/mL in 23 of 38 and 20 of 38 isolates on blood and brucella agar, respectively. Minimum inhibitory concentration values of TIG were substantially different ranging between 0.064-0.25 mu g/mL on blood agar. However, MIC values of TIG were similar on brucella agar with 0.25 mu g/mL in 15 of 38 isolates and 0.5 mu g/mL in 10 of 38 isolates. In conclusion, although ERT and TIG were effective against B. melitensis isolates in vitro, further studies are needed in order to determine the use of these novel drugs in treatment of brucellosis.