Serological diagnostics in the detection of IgG autoantibodies against human collagen VII in epidermolysis bullosa acquisita: a multicentre analysis.

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Schmidt T., Hoch M., Jad S. S. L., Solimani F., Di Zenzo G., Marzano A. V., ...Daha Fazla

The British journal of dermatology, cilt.177, sa.6, ss.1683-1692, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 177 Sayı: 6
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1111/bjd.15800
  • Dergi Adı: The British journal of dermatology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1683-1692
  • Akdeniz Üniversitesi Adresli: Evet

Özet

BackgroundEpidermolysis bullosa acquisita (EBA) is a rare, potentially devastating autoimmune disease of the skin. IgG autoantibodies directed against type VII collagen (Col7), the major component of anchoring fibrils, induce skin fragility leading to cutaneous and mucocutaneous blister formation, which is mostly of a scarring phenotype. Thus, powerful and reproducible diagnostic assays are critical to establish the diagnosis of EBA early to avoid irreversible sequelae.