Serological diagnostics in the detection of IgG autoantibodies against human collagen VII in epidermolysis bullosa acquisita: a multicentre analysis.

Schmidt, T.; Hoch, M.; Jad, S.; Solimani, F.; Di Zenzo, G.; Marzano, A.; Goebeler, M.; Cozzani, E.; Kern, J.; Sitaru, C.; Jukic, I.; Sardy, M.; Uzun, SONER; Jedlickova, H.; Glaeser, R.; Kaneda, M.; Eming, R.; Goepel, G.; Ishii, N.; Greene, B.; Hashimoto, T.; Hertl, M.

doi:10.1111/bjd.15800

Serological diagnostics in the detection of IgG autoantibodies against human collagen VII in epidermolysis bullosa acquisita: a multicentre analysis.

Schmidt T., Hoch M., Jad S. S. L., Solimani F., Di Zenzo G., Marzano A. V., ...Daha Fazla

The British journal of dermatology, cilt.177, sa.6, ss.1683-1692, 2017 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 177 Sayı: 6
Basım Tarihi: 2017
Doi Numarası: 10.1111/bjd.15800
Dergi Adı: The British journal of dermatology
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1683-1692
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Akdeniz Üniversitesi Adresli: Evet

Özet

BackgroundEpidermolysis bullosa acquisita (EBA) is a rare, potentially devastating autoimmune disease of the skin. IgG autoantibodies directed against type VII collagen (Col7), the major component of anchoring fibrils, induce skin fragility leading to cutaneous and mucocutaneous blister formation, which is mostly of a scarring phenotype. Thus, powerful and reproducible diagnostic assays are critical to establish the diagnosis of EBA early to avoid irreversible sequelae.