Serological diagnostics in the detection of IgG autoantibodies against human collagen VII in epidermolysis bullosa acquisita: a multicentre analysis.

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Schmidt T., Hoch M., Jad S. S. L., Solimani F., Di Zenzo G., Marzano A. V., ...More

The British journal of dermatology, vol.177, no.6, pp.1683-1692, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 177 Issue: 6
  • Publication Date: 2017
  • Doi Number: 10.1111/bjd.15800
  • Journal Name: The British journal of dermatology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1683-1692
  • Akdeniz University Affiliated: Yes

Abstract

BackgroundEpidermolysis bullosa acquisita (EBA) is a rare, potentially devastating autoimmune disease of the skin. IgG autoantibodies directed against type VII collagen (Col7), the major component of anchoring fibrils, induce skin fragility leading to cutaneous and mucocutaneous blister formation, which is mostly of a scarring phenotype. Thus, powerful and reproducible diagnostic assays are critical to establish the diagnosis of EBA early to avoid irreversible sequelae.