The Neuropsychiatric Inventory Scores Change Across the Mini Mental State Examination Ranges in Patients With Alzheimer's Disease: A Multicenter Study in Turkey

Yener G. G.

COGNITIVE AND BEHAVIORAL NEUROLOGY, sa.4, ss.264-269, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1097/wnn.0b013e3181c14737
  • Dergi Adı: COGNITIVE AND BEHAVIORAL NEUROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Sayfa Sayıları: ss.264-269
  • Anahtar Kelimeler: Alzheimer's disease, Mini Mental State Examination, Neuropsychiatric Inventory, PSYCHOLOGICAL SYMPTOMS, BEHAVIORAL DISTURBANCES, VASCULAR DEMENTIA, DISRUPTIVE BEHAVIOR, CACHE COUNTY, FOLLOW-UP, PREVALENCE, AGITATION, DONEPEZIL, IMPAIRMENT
  • Akdeniz Üniversitesi Adresli: Hayır

Özet

Objective: To investigate neuropsychiatric manifestations in patients at various stages of Alzheimer's disease (AD). Background: Several earlier studies reported high prevalence of neuropsychiatric symptoms in patients with AD; to date, no such Study has been conducted in Turkey. Method: We evaluated 217 patients with AD from 18 referral centers across Turkey using a web-based dementia data registry. The Mini Mental State Examination and the Neuropsychiatric Inventory (NPI) were used to evaluate the global cognitive function, and assessment of neuropsychiatric symptoms, respectively. We classified the patients into mild, moderate, and severe stages on the basis of their Mini Mental State Examination scores. We assessed group differences and correlations between the degree of AD severity and NPI values. Results: The highest NPI scores were seen in patients with severe AD. The mean composite scores for apathy, anxiety.. and depression were the highest. The prevalence of any behavioral symptom was 86%. There was no difference in the behavioral domain between the groups or between the referral centers. Moderate correlation was found between the severity of AD and the total NPI score. The caregivers' NPI distress scores varied among referral centers. Conclusions: The prevalence of behavioral disturbance in AD is high and similar to earlier studies, yet regional differences are seen in caregivers' reactions to behavioral symptoms.