Akademik Veri Yönetim Sistemi
24. Ulusal Anatomi Kongresi, İstanbul, Türkiye, 19 - 21 Eylül 2024, ss.24-25
Abstract
Objective: This
study aimed to investigate the time-dependent effects of chitosan and
therapeutic ultrasound on the healing of Achilles tendon injuries and to
determine the most effective treatment method by comparing tendon healing
across different groups at various time intervals.
Materials and Methods: Adult
male Wistar albino rats were divided into five groups. Group I (Control, n =8)
received no intervention. Group II (Injured, n = 8) underwent surgical
transection of the right Achilles tendon at the midline and repair using the
Kessler method. Group III (Chitosan, n = 8) received application of chitosan
solution following Kessler repair. Group IV (Ultrasound, n = 8) underwent
therapeutic ultrasound treatment after Kessler repair. Group V (Ultrasound +
Chitosan, n = 8) received both chitosan solution and therapeutic ultrasound
after Kessler repair. The original tissue images were converted to RGB images,
and the amount of collagen fibers was accurately and efficiently measured using
ImageJ/Fiji software.
Results: Collagen
fibers in the ultrasound and chitosan groups exhibited morphology most similar
to the control group at the 6-week mark. The collagen fibers in these groups
were more regular, more abundant, and surrounded by a much smoother
extracellular matrix compared to the injury group.
Conclusion: Among
all treatment groups, the collagen fibers in the ultrasound + chitosan group
were observed to be closest to the control group morphology at the 6-week mark.
The therapeutic ultrasound and chitosan methods were found to be effective in
promoting tendon healing and improving collagen structure.
Keywords: Tendon healing, chitosan, ultrasound