The effect of KNK437, a heat shock protein inhibitor, on angiogenesis of endothelial cells

Sahin E., ŞAHİN M., GÜMÜŞLÜ S.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.42, no.4, pp.597-604, 2012 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 4
  • Publication Date: 2012
  • Doi Number: 10.3906/sag-1105-14
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.597-604
  • Keywords: Hyperthermia, angiogenesis, KNK437, quercetin, tube formation, endothelial cells, IN-VITRO, CANCER, QUERCETIN, THERMOTOLERANCE, HYPERTHERMIA, ACQUISITION, FLAVONOIDS, DISEASES, VIVO
  • Akdeniz University Affiliated: Yes

Abstract

Aim: Hyperthermia is an effective therapy for cancer and tumor angiogenesis. However, the development of thermotolerance is an important problem. We aimed to investigate the effects of KNK437 and quercetin on angiogenesis and thermotolerance in endothelial cells (ECs).