Estrogen-mediated regulation of p38 mitogen-activated protein kinase in human endometrium
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol.91, no.6, pp.2349-2357, 2006 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 91 Issue: 6
- Publication Date: 2006
- Doi Number: 10.1210/jc.2005-2132
- Journal Name: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.2349-2357
- Open Archive Collection: AVESIS Open Access Collection
- Akdeniz University Affiliated: No
Abstract
Context: Estrogen predominantly exerts its biological effects through the genomic pathway by binding to its intracellular receptors, interacting with the estrogen response element located in the promoter region of the target gene, and thus regulating gene transcription. There has been an increasing body of evidence regarding nongenomic actions of estrogen. Estrogen activates multiple signaling cascades, including the MAPK pathway. p38 MAPK plays key roles in mediating apoptosis, proliferation, and inflammation, which all take place in the endometrium during cyclical changes under the influence of estrogen.