Research Information System
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol.91, no.6, pp.2349-2357, 2006 (SCI-Expanded, Scopus)
Context: Estrogen predominantly exerts its biological effects through the genomic pathway by binding to its intracellular receptors, interacting with the estrogen response element located in the promoter region of the target gene, and thus regulating gene transcription. There has been an increasing body of evidence regarding nongenomic actions of estrogen. Estrogen activates multiple signaling cascades, including the MAPK pathway. p38 MAPK plays key roles in mediating apoptosis, proliferation, and inflammation, which all take place in the endometrium during cyclical changes under the influence of estrogen.