Effect of intratumoral lymphocyte density on the disease-free survival and overall survival in malignant epithelial tumors of the ovary
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, cilt.30, sa.5, ss.523-526, 2009 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 30 Sayı: 5
- Basım Tarihi: 2009
- Dergi Adı: EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.523-526
- Anahtar Kelimeler: Ovarian carcinomas, Intratumoral T lymphocytes, VEGF, ENDOTHELIAL GROWTH-FACTOR, CD8(+) T-LYMPHOCYTES, PROGNOSTIC-FACTOR, INFILTRATING LYMPHOCYTES, CANCER, EXPRESSION, CELLS, ANGIOGENESIS
- Akdeniz Üniversitesi Adresli: Evet
Özet
Malignant epithelial ovarian tumors are the fifth most common cancer of females which has the highest mortality rate among gynecological malignancies. Tumor-specific or related antigens that induce an immune response have been defined in tumors. Intratumoral T lymphocytes recognize these antigens and induce a cytolytic activity. Vascular endothelial growth factor (VEGF) is a potent angiogenic factor expressed in many tumors. In this study, we Studied the relation between clinicopathological findings and intratumoral T lymphocyte and VEGF expressions in malignant epithelial ovarian tumors. The presence of VEGF in ovarian surface epithelial carcinomas and CD3, CD4 and CD8 antibodies in tumor-infiltrated lymphocytes were investigated in 63 cases with an immunohistochemical method. Positive-stained intratumoral lymphocytes were graded on a scale of 0 to 3 (0 -> 0, + 1 -><= 5, + 2 -> 6-19, + 3 ->>= 20). VEGF was assessed according to the staining intensity (0: negative, +1: weak, +2: moderate, +3: strong). CD3 positivity was observed in intratumoral lymphocytes in all cases while only CD4 and CD8 positivities were observed in 30% and 80%, respectively. VEGF was positive in 73% of the cases. No significant relation was observed between VEGF expression and presence of intratumoral T lymphocyte and clinicopathological parameters. Moreover, they did not have any significant effect on disease-free survival and overall survival.