Treatment Outcomes and Survival Study of Gastric Cancer Patients: A Retrospective Analysis in an Endemic Region


Creative Commons License

Başaran H., Koca T., Çerkeşli A. K., Arslan D., Karaca S.

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, cilt.16, sa.5, ss.2055-2060, 2015 (Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 5
  • Basım Tarihi: 2015
  • Dergi Adı: ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
  • Derginin Tarandığı İndeksler: Scopus, EMBASE, MEDLINE, Index Copernicus
  • Sayfa Sayıları: ss.2055-2060
  • Akdeniz Üniversitesi Adresli: Hayır

Özet

Abstract

Purpose: To present information about prognostic factors of gastric cancer patients treated in our Erzurum

center including age, gender, tumour location, pathological grade, stage and the effect of treatment on survival.

Materials and Methods: This retrospective study was performed on patients who applied to our clinic and

diagnosed as gastric cancer. Age and gender of the patients, primary location, histopathological characteristics,

TNM stage of the gastric cancers (GCs), treatment applied, oncological treatment modalities and survival

outcomes were studied. A univariate analysis of potential prognostic factors was performed with the log-rank

test for categorical factors and parameters with a p value < 0.05 at the univariate step were included in the

multivariate regression. Results: A total of 228 patients with a confirmed diagnosis of gastric cancer were

included in the study with a male/female ratio of 1.47. Median follow-up period was estimated as 22.3 (range, 3

to 96) months. When diagnosis of the patients at admission was analysed, stage III patients were most frequently

encountered (n=147; 64.5%). One hundred and twenty-six (55.3%) underwent surgical treatment, while 117

(51.3%) were given adjuvant chemotherapy. Median overall survival time was 18.0 (±1.19) months. Mean overall

survival rates for 1, 2, 3 and 5 years were 68±0.031%, 36±0.033%, 24±0.031% and 15.5±0.036%, respectively.

Univariate variables found to be significant for median OS in the multivariate analysis were evaluated with Cox

regression analysis. A significant difference was found among TNM stage groups, location of the tumour and

postoperative adjuvant treatment receivers (p values were 0.011, 0.025 and 0.001, respectively). Conclusions: This

study revealed that it is possible to achieve long-term survival of gastric cancer with early diagnosis. Besides, in

locally advanced GC patients, curative resection followed by adjuvant concomitant chemoradiotherapy based

on the McDonald regimen was an independent prognostic factor for survival.

Keywords: Gastric cancer - overall survival - prognostic factors - chemoradiotherapy