Histamine induces the neuronal hypertrophy and increases the mast cell density in gastrointestinal tract

Keles N., Arican R. Y., COŞKUN M., ELPEK G. Ö.

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, vol.64, no.7-8, pp.713-716, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 64 Issue: 7-8
  • Publication Date: 2012
  • Doi Number: 10.1016/j.etp.2011.01.005
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.713-716
  • Keywords: Histamine, Mast cell density, Neuronal hypertrophy, Image analysis, Mice, IRRITABLE-BOWEL-SYNDROME, SUBMUCOUS PLEXUS, IMMUNE, NERVES, APPENDICITIS, RECEPTOR, H-3
  • Akdeniz University Affiliated: Yes


Histamine is an endogenous biogenic amine that is synthesized from the basic amino acid histidine. Ability to mimic anaphylaxis is one of the first described functions of histamine and it has been demonstrated that histamine plays a significant role in the regulation of immune system and neuronal function, influences neuronal morphology and is involved in mast cells (MCs) chemotaxis. MCs as histamine releasers, may thus also interact with neuronal function. In the present study, we aimed to evaluate the role of histamine on mast cell density and neuronal morphology in the gastrointestinal tract of the mouse.