Plasma homocysteine levels in patients with beta-thalassaemia major

ÖZDEM S., Kupesiz A., Yesilipek A.

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, cilt.68, sa.2, ss.134-139, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 68 Sayı: 2
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1080/00365510701516343
  • Dergi Adı: SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.134-139
  • Anahtar Kelimeler: folic acid, homocysteine, oxidative stress, thalassaemia, vitamin B12, ALPHA-HEMOGLOBIN CHAINS, RISK-FACTOR, ANTIOXIDANT CAPACITY, METHIONINE SYNTHASE, OXIDATIVE STRESS, FOLATE, METABOLISM, MODEL, IRON, COMPLICATIONS
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Objective . We investigated the level of homocysteine (HCY) and its relation with vitamin B12, folate and oxidative stress in patients with beta-thalassaemia major. Material and methods. Plasma HCY, methionine, advanced oxidation protein products (AOPP) and serum vitamin B12, folate, ferritin and total antioxidant capacity (TAC) were determined in 32 thalassaemic patients and 27 control subjects. Results . HCY (6.44+/-0.44 versus 8.71+/-0.57 mu mol/L), methionine (12.5+/-71.8 versus 22.2+/-3.8 mu mol/L), folate (9.14+/-0.48 versus 15.38+/-0.71 nmol/L) and TAC (0.34+/-0.03 versus 0.56+/-0.03 mmol/L) significantly decreased in thalassaemic patients, whereas AOPP (20.26+/-1.8 versus 11.30+/-0.2 mol/L) and ferritin (3481.0+/-512 versus 46.9+/-4.6 ng/mL) significantly increased. Vitamin B12 levels were similar in both groups (259.1+/-16.6 versus 228.9+/-7.4 pmol/L). Conclusions . These findings suggest that increased and uncompensated oxidative stress may lead to an increment in HCY catabolism in thalassaemic patients.