The Effect of Quinapril Treatment on Insulin Resistance, Leptin and High Sensitive C-Reactive Protein in Hypertensive Patients

Sari F., Eray E., SARI R.

CLINICAL AND EXPERIMENTAL HYPERTENSION, vol.33, no.8, pp.548-551, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 8
  • Publication Date: 2011
  • Doi Number: 10.3109/10641963.2011.577481
  • Journal Name: CLINICAL AND EXPERIMENTAL HYPERTENSION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.548-551
  • Keywords: hypertension, insulin resistance, high sensitive C-reactive protein, leptin, angiotensin converting enzyme inhibitors, SYMPATHETIC-NERVOUS-SYSTEM, ANGIOTENSIN-II, BLOOD-PRESSURE, ENDOTHELIAL DYSFUNCTION, METABOLIC SYNDROME, PLASMA LEPTIN, INFLAMMATION, LOSARTAN, OBESITY, RATS
  • Akdeniz University Affiliated: Yes

Abstract

The aim of the study was to evaluate the effect of quinapril on HOMA-IR, high sensitive C-reactive protein and leptin. Total 54 hypertensive and 24 control subjects were included in this study. Blood pressure, leptin, high sensitive C-reactive protein, and HOMA-IR were determined at baseline and after 3 months quinapril treatment. After treatment with quinapril HOMA-IR (p = 0.04), high sensitive C-reactive protein (p = 0.027), and leptin (p = 0.046) were decreased in hypertensive patients. Quinapril may be used as a therapy for improving blood pressure as well as the insulin resistant, hyperleptinemic, and low-grade inflammatory state in hypertension.