Increased mean platelet volume in chronic hepatitis B patients with inactive disease

TURHAN Ö., ÇOBAN E., İNAN D., YALÇIN A. N.

MEDICAL SCIENCE MONITOR, cilt.16, sa.4, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 4
  • Basım Tarihi: 2010
  • Dergi Adı: MEDICAL SCIENCE MONITOR
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: platelet activation, hepatitis B virus, atherosclerosis, mean platelet volume, CORONARY-ARTERY-DISEASE, MYOCARDIAL-INFARCTION, VIRUS-INFECTION, CAROTID ATHEROSCLEROSIS, RISK, ACTIVATION, SIZE, SEROPOSITIVITY, POPULATION, PLASMA
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Background: Hepatitis B virus (HBV) infection is a major public health problem worldwide, responsible for considerable morbidity and mortality from chronic liver disease. Conflicting findings on the possible association between HBV surface antigen (HBsAg) positivity, indicating inactive HBsAg car carrier status, and atherosclerosis have been reported. Platelet activation and aggregation are central processes in the pathophysiology of atherosclerosis. Mean platelet volume, a determinant of plate platelet activation, is a newly emerging risk factor for atherothrombosis. Elevated MPV levels have been identified as an independent risk factor for myocardial infarction in patients with coronary heart disease, and for death or recurrent vascular events after myocardial infarction. Moreover, increased platelet size has been reported in patients with vascular risk factors such as diabetes mellitus, in patients with acute ischemic stroke, and essential hypertension. According to our knowledge, there has been no previous study of MPV in inactive HBsAg carriers. Therefore, we have investigated the possible association between HBsAg positivity and MPV.