Akademik Veri Yönetim Sistemi
Turk Hijyen ve Deneysel Biyoloji Dergisi, cilt.79, sa.2, ss.267-278, 2022 (Scopus)
© 2022. Turk Hijyen ve Deneysel Biyoloji Dergisi. All Rights Reserved.Objective: Stress causes neuropsychiatric diseases such as depression and anxiety in the person by affecting emotions, opinions and behaviors. In this study, the aim was to investigate the therapeutic effects of tDCS on depression and anxiety disorders that occur after subchronic stress. Methods: 40 male Wistar rats weighing 290-310 g were divided into four groups as control, tDCS, stress and stress+tDCS. Restraint stress was applied for 7 days (2 h/day) as a stress model. Rats in the tDCS and stress+tDCS groups were performed the stimulation of 1 mA anodal tDCS for three consecutive days from the 5th day of stress exposure. On the 7th day of the experiment, the anxiety and depression behaviors of the rats were evaluated with the open field test and the elevated plus maze test. Results: No significant changes were found in the locomotor activity, elevated plus maze test data between control and tDCS groups. In the stress group rats compared to the control group, there was a significant decrease in the locomotor activity levels (p <0.001), while a significant increase was observed in the data indicator of anxiety (p<0.001). In the stress + tDCS group compared to the control group, there was a significant decrease in the data indicator of anxiety following tDCS application (p <0.05), but no significant difference was found in the results of locomotor activity. Conclusion: In conclusion, our data showed that tDCS stimulation may have an effect on sub-chronic stress-induced anxiety and depression behaviors.