Oxidative Status in Epileptic Children Using Carbamazepine

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Tutanc M., Aras M., Dokuyucu R., Altas M., Zeren C., Arica V., ...More

IRANIAN JOURNAL OF PEDIATRICS, vol.25, no.6, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 6
  • Publication Date: 2015
  • Doi Number: 10.5812/ijp.3885
  • Journal Name: IRANIAN JOURNAL OF PEDIATRICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Carbamazepine, Antioxidant Capacity, Oxidant Status, TOTAL ANTIOXIDANT CAPACITY, OXYGEN-FREE-RADICALS, ANTIEPILEPTIC DRUGS, LIPID-PEROXIDATION, PASSIVE SMOKING, TRACE-ELEMENTS, REDOX STATUS, STRESS, GLUTATHIONE, DYSFUNCTION
  • Akdeniz University Affiliated: Yes

Abstract

Background: There is an increasing attention towards the relationship between oxidative stress and epilepsy. The effect of antiepileptic drugs on oxidant status is of major interest. Antiepileptic drugs can increase levels of free radicals, which consequently might lead to seizures. Carbamazepine (CBZ) is an antiepileptic drug commonly used in childhood and adolescence.