Genotoxic and genoprotective effects of phytoestrogens: a systematic review

Tagortı G., Yalçın B., Güneş M., Burgazlı A. Y., Kaya B.

DRUG AND CHEMICAL TOXICOLOGY, vol.46, no.4, pp.1-13, 2023 (SCI-Expanded)

  • Publication Type: Article / Review
  • Volume: 46 Issue: 4
  • Publication Date: 2023
  • Doi Number: 10.1080/01480545.2022.2146134
  • Journal Name: DRUG AND CHEMICAL TOXICOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, Environment Index, Food Science & Technology Abstracts, International Pharmaceutical Abstracts, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.1-13
  • Akdeniz University Affiliated: Yes

Abstract

Phytoestrogens are xenoestrogens found in plants with a myriad of health benefits. However, variousstudies reported the genotoxic effects of these substances. Thus, we reviewedin vitroandin vivostud-ies published in PubMed, Scopus, and Web of Science to evaluate the genotoxic and the genoprotec-tive potential of phytoestrogens. Only studies written in English and intended to study commerciallyavailable phytoestrogens were included. The screening was performed manually. Moreover, the under-lying mechanism of action of phytoestrogens was described. Around half of those studies (43%)reported genoprotective results. However, several studies revealed positive results for genotoxicity withspecific model organisms and with dose/concentration dependence. The assessment of the selectedarticles showed substantial differences in the used concentrations and a biphasic response wasrecorded in some phytoestrogens. As far as we know, this is the first study to assess the genotoxic andgenoprotective effects of phytoestrogens systematically.