A comparative study of cytotoxic, membrane and DNA damaging effects of Origanum majorana's essential oil and its oxygenated monoterpene component linalool on parental and epirubicin-resistant H1299 cells

Erdogan A., ÖZKAN A.

BIOLOGIA, cilt.68, sa.4, ss.754-761, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 68 Sayı: 4
  • Basım Tarihi: 2013
  • Doi Numarası: 10.2478/s11756-013-0196-0
  • Dergi Adı: BIOLOGIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.754-761
  • Anahtar Kelimeler: Origanum majorana, essential oil, linalool, DNA damage, membrane damage, parental and epirubicin-resistant H1299 cell line, MITOCHONDRIAL-MEMBRANE, ANTICANCER ACTIVITY, LIPID-PEROXIDATION, AQUEOUS EXTRACTS, REACTIVE OXYGEN, ANTIOXIDANT, MECHANISMS, INHIBITION, CARVACROL, MARJORAM
  • Akdeniz Üniversitesi Adresli: Evet

Özet

In this study, cytotoxic, membrane and DNA damaging effects of the essential oil from Origanum majorana and its oxygenated monoterpene component linalool were tested on parental and epirubicin-resistant (drug-resistant) human lung cancer cell lines (H1299). Essential oil's and linalool's cytotoxicities were examined and parental cells were found more sensitive to the essential oil's and linalool's cytotoxicities than drug-resistant cells. O. majorana essential oil had more effective membrane damaging effect than linalool on parental cells, while in drug-resistant H1299 cells, linalool had more effective membrane damaging effect than the essential oil. O. majorana essential oil possessed more effective DNA damaging effect than linalool on both parental and drug-resistant cells. The conclusions from this study suggest that O. majorana essential oil and linalool exhibit cytotoxic, membrane and DNA damaging effects. They thus need further investigation as potential therapeutic agents for human lung cancer.