The interaction between invariant Natural Killer T cells and the mucosal microbiota

Creative Commons License

Hapil F. Z., WINGENDER G.

IMMUNOLOGY, cilt.155, sa.2, ss.164-175, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 155 Sayı: 2
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1111/imm.12958
  • Dergi Adı: IMMUNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.164-175
  • Anahtar Kelimeler: microbiota, mucosal immunology, invariant Natural Killer T cells, NKT CELLS, IMMUNE-RESPONSES, INKT CELLS, HELICOBACTER-PYLORI, CYTOKINE PRODUCTION, GLYCOLIPID ANTIGEN, ADAPTIVE IMMUNITY, EPITHELIAL CD1D, DENDRITIC CELLS, GUT MICROBIOTA
  • Akdeniz Üniversitesi Adresli: Hayır

Özet

The surface of mammalian bodies is colonized by a multitude of microbial organisms, which under normal conditions support the host and are considered beneficial commensals. This requires, however, that the composition of the commensal microbiota is tightly controlled and regulated. The host immune system plays an important role in the maintenance of this microbiota composition. Here we focus on the contribution of one particular immune cell type, invariant Natural Killer T (iNKT) cells, in this process. The iNKT cells are a unique subset of T cells characterized by two main features. First, they express an invariant T-cell receptor that recognizes glycolipid antigens presented by CD1d, a non-polymorphic major histocompatibility complex class I-like molecule. Second, iNKT cells develop as effector/memory cells and swiftly exert effector functions, like cytokine production and cytotoxicity, after activation. We outline the influence that the mucosal microbiota can have on iNKT cells, and how iNKT cells contribute to the maintenance of the microbiota composition.