Akademik Veri Yönetim Sistemi
GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, cilt.12, sa.5, ss.1002-1006, 2022 (SCI-Expanded)
Purpose To analyze the postoperative foveal avascular zone (FAZ) area, superficial capillary plexus (SCP), deep capillary
plexus (DCP) vascular densities (VD), and retinal layers after cross-linking (CXL) for keratoconus treatment.
Methods Twenty-seven eyes with cross-linking treatment for keratoconus were included in the study. Foveal avascular
zone (FAZ) area, SCP VD, DCP VD, and retinal layers were evaluated by using optical coherence tomography angiography
(OCTA). OCTA measurements were made at preoperative, first week, and first and sixth months after the surgery. In addition,
corneal topography measurements were also made.
Results Although there was a decrease in corneal thickness in the follow-up of the patients, there was no significant difference
in axial length and anterior chamber depth. There was no significant difference in full retinal thickness in the foveal
and parafoveal areas. While there was a significant increase in retinal nerve fiber layer (RNFL) thickness in the foveal area
(p = 0.032, p = 0.015, p = 0.017; preoperative values compared to first week, first month, and sixth month respectively), there
was a decrease in ganglion cell layer (GCL) thickness in the parafoveal area in the postoperative sixth month (p = 0.028).
There was no difference in FAZ measurements. In the parafoveal area, a decrease was observed in SCP VD in the sixthmonth
control (p = 0.019). There was a significant increase in DCP VD in the foveal area (p = 0.008, p = 0.043, p = 0.040).
The preoperative mean CDVA (corrected distance visual acuity) was 0.37 ± 0.16 logMAR and postoperative sixth month
mean CDVA was 0.39 ± 0.15. There was no significant difference in visual acuity (p = 0.71).
Conclusion Keratoconus patients successfully treated with CXL had significant changes in retinal layers and vessel density
in the superficial and deep retinal plexus.