Efficacy of 5-Fluorouracil in inhibition of unintended bone formation in spinal surgery: a histological evaluation on a rat model of spontaneous spinal fusion

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Kiter E., Er E., Sen Turk N., Oto M., Akkaya S.

ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA, vol.48, no.1, pp.86-91, 2014 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 48 Issue: 1
• Publication Date: 2014
• Doi Number: 10.3944/aott.2014.3161
• Journal Name: ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
• Page Numbers: pp.86-91
• Keywords: 5-Fluorouracil, inhibition of spinal fusion, spontaneous spinal fusion, FLEXOR TENDON REPAIR, YOUNG-CHILDREN, HARRINGTON INSTRUMENTATION, FIBRIN GLUE, ARTHRODESIS, SCOLIOSIS, TRABECULECTOMY, DEFORMITIES, MANAGEMENT, PROTEIN
• Akdeniz University Affiliated: Yes

Abstract

Objective: The aim of this study was to investigate the influence of the antiproliferative agent 5-Fluorouracil (5FU) over inhibition of spinal bone formation in an experimental rat model.