Biochemically and histopathologically comparative review of thiamine's and thiamine pyrophosphate's oxidative stress effects generated with methotrexate in rat liver

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Demiryilmaz I., SENER E., Cetin N., Altuner D., Suleyman B., ALBAYRAK F., ...Daha Fazla

MEDICAL SCIENCE MONITOR, cilt.18, sa.12, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 12
  • Basım Tarihi: 2012
  • Doi Numarası: 10.12659/msm.883591
  • Dergi Adı: MEDICAL SCIENCE MONITOR
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: thiamine pyrophosphate, thiamine, methotrexate, hepatotoxicity, rat, DNA-DAMAGE, VITAMIN-C, INJURY, ACID, ANTIOXIDANT, 8-OXOGUANINE, INFLAMMATION, SUPEROXIDE, METABOLISM, APOPTOSIS
  • Akdeniz Üniversitesi Adresli: Hayır

Özet

Background: Oxidative liver injury occurring with methotrexate restricts its use in the desired dose. Therefore, whether or not thiamine and thiamine pyrophosphate, whose antioxidant activity is known, have protective effects on oxidative liver injury generated with methotrexate was comparatively researched in rats using biochemical and histopathological approaches.