Akademik Veri Yönetim Sistemi
CHEMISTRYSELECT, cilt.10, sa.9, ss.2365-6549, 2025 (SCI-Expanded)
Nickel oxide nanoparticles (NiO NPs) synthesized with polyvinylpyrrolidone (PVP) demonstrate promising antimicrobial properties for biomedical applications. NiO NPs were synthesized using PVP stabilizers of varying molecular weights: PVP K10 (average MW 10,000 dalton), PVP K15 (average MW 15,000 dalton), and PVP K40 (average MW 40,000 dalton), employing a hydrothermal method. The NiO NPs synthesized with PVP10K exhibited smaller particle sizes ranging from 30 to 40 nm and a larger surface area. Optimal synthesis conditions for NiO NPs were established as follows: 100 °C for 6 h for K1-6/100, 120 °C for 6 h for K1-6/120, and 120°C for 12 h for K1 12/120. TEM images revealed that the NiO NPs possessed a hexagonal morphology with sizes ranging between 10 and 30 nm. XRD analysis confirmed the crystalline structure of the NiO NPs, whereas FTIR spectra validated the presence of Ni─O bonds. UV–vis detected the optical bandgap within the range of 3.06 to 3.31 eV. The minimum inhibitory concentration assays indicated that the compound K1-12/120 exhibited the most pronounced antibacterial effect against Escherichia coli at a concentration of 256 μg/mL and against Staphylococcus aureus at a concentration of 128 μg/mL. Moreover, Gram-positive bacteria were found to be more susceptible to NiO NPs.