Investigation of Antibacterial Effects of Streptomycin Sulfate-Loaded PMMA/PEO/Bis-Chalcone Derivatives-Based Fibers

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Koçer K. N., Nohut Maşlakçi N., Eren E., Çevikbaş H., Ulusoy S., Biçer A., ...More

International Joint Science Congress of Materials and Polymers (ISCMP), Burdur, Turkey, 29 September - 01 November 2021, pp.122, (Summary Text)

• Publication Type: Conference Paper / Summary Text
• City: Burdur
• Country: Turkey
• Page Numbers: pp.122
• Akdeniz University Affiliated: Yes

Abstract

In this study, fibers were obtained by electrospinning technique to increase the bioavailability of biocompatible polymethyl methacrylate (PMMA)/polyethylene oxide (PEO)/bis-chalcone derivatives ((2E,6E)‐2,6‐bis(4-nitrobenzylidene)cyclohexanone and (2E,6E)‐2,6‐bis[(thiophen‐2‐yl)methylene]cyclohexanone) containing Streptomycin sulfate as a model drug in two different ratios (30 and 60 mg). The antibacterial effects of drug-containing and non-drug fibers against Bacillus cereus and Escherichia coli were investigated. As a result, it was observed that the drug-free fibers did not have any antibacterial effect, while the drug-containing fibers completely destroyed B. cereus and E. coli. Our findings can provide insight into new fibers prepared with antimicrobial compounds for wound dressing applications.