Evaluation of bone marrow findings in hemodialysis patients with erythropoietin-resistant anemia

Yilmaz M., Karakuş V., Kaya E., İLHANLI N., Huddam B.

Therapeutic Apheresis and Dialysis, cilt.28, sa.2, ss.218-224, 2024 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 2
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1111/1744-9987.14086
  • Dergi Adı: Therapeutic Apheresis and Dialysis
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, MEDLINE
  • Sayfa Sayıları: ss.218-224
  • Anahtar Kelimeler: anemia, bone marrow findings, chronic kidney disease, hemodialysis patients, unresponsiveness to erythropoiesis-stimulating agents
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Introduction: Treatment with erythropoietin-stimulating agents (ESAs) is widely used in anemia of chronic kidney disease (CKD). Acquired ESA resistance is an important problem. The aim of this study is to examine the bone marrow findings in hemodialysis patients with ESA-resistant anemia. Methods: The data of 210 patients with acquired ESA resistance were reviewed retrospectively. The patients were divided into groups according to having diagnosis of dysplasia and hematological disease, and survival analysis was performed. Results: A total of 26 patients were included in the study. While dysplasia was present in 10 (38.5%) patients, five of them were diagnosed hematologically. When survival analysis was performed between those with and without a hematological diagnosis, a difference in survival was observed against the group with the diagnosis (24.4 vs. 72 months, p = 0.045). Conclusion: Unresponsiveness to ESA treatment in CKD patients or a decrease in one of the other cell lines along with hemoglobin, it would be appropriate to perform early bone marrow examination.