FoxO transcription factors 1 regulate mouse preimplantation embryo development

KUŞCU N., Gungor-Ordueri N. E., Sozen B., ADIGÜZEL D., ÇELİK ÖZENCİ Ç.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, cilt.36, sa.10, ss.2121-2133, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 10
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1007/s10815-019-01555-1
  • Dergi Adı: JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2121-2133
  • Anahtar Kelimeler: FoxO, Preimplantation embryo, Sirtuin1, Resveratrol, Oxidative stress, Apoptosis, RESVERATROL PROTECTS, OOCYTE MATURATION, CELL, STRESS, SIRT1, APOPTOSIS, DISRUPTION, METABOLISM, EXPRESSION, INTERFACE
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Purpose The aim of the present study is to investigate role of FoxO transcription factors in preimplantation embryo development by knocking down FoxO1, FoxO3, and FoxO4 genes and also to assess cell cycle arrest related proteins, p53 and p21, and apoptosis-related proteins, fas ligand (FASL), and cleaved caspase 3.