Enhanced anticancer effect of cetuximab combined with stabilized silver ion solution in EGFR-positive lung cancer cells

ÖZKAN A., Erdogan A., Ozkan O., Manguoglu E., KİRAZ N.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.44, no.4, pp.426-437, 2019 (SCI-Expanded, Scopus, TRDizin) identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 4
  • Publication Date: 2019
  • Doi Number: 10.1515/tjb-2018-0033
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.426-437
  • Keywords: Cetuximab, stabilized silver solution, apoptosis, lung cancer, combined treatment, GROWTH-FACTOR RECEPTOR, EPIRUBICIN-RESISTANT, HYDROGEN-PEROXIDE, TYROSINE KINASE, CARCINOMA, EXPRESSION, EFFICACY, QUANTITATION, COMBINATION, APOPTOSIS
  • Akdeniz University Affiliated: Yes

Abstract

Background: Cytotoxic, antiproliferative, cell cycle inhibitive, oxidative and apoptotic effects of cetuximab [antibody for epidermal growth factor receptor (EGFR)] alone and together with stabilized silver ion solution (St-Ag) on P-H1299, R-H1299, A-431 and A-549 cells were investigated.