Erythrocyte, plasma, and serum antioxidant activities in untreated toxic multinodular goiter patients

ALICIGÜZEL Y., Ozdem S., Ozdem S., KARAYALÇIN U., Siedlak S., Perry G., ...Daha Fazla

FREE RADICAL BIOLOGY AND MEDICINE, cilt.30, sa.6, ss.665-670, 2001 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 6
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1016/s0891-5849(00)00509-8
  • Dergi Adı: FREE RADICAL BIOLOGY AND MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.665-670
  • Anahtar Kelimeler: antioxidant, erythrocyte, hyperthyroidism, plasma, serum, free radicals, VITAMIN-E STATUS, SUPEROXIDE-DISMUTASE, LIPID-PEROXIDATION, GLUTATHIONE-PEROXIDASE, THYROID-HORMONE, ANIMAL-TISSUES, SELENIUM, CATALASE, HYPERTHYROIDISM, AUTOXIDATION
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Erythrocyte, plasma, and serum antioxidant activities were studied in patients with newly diagnosed and untreated toxic multinodular hyperthyroid goiter and compared to healthy control subjects. Erythrocyte antioxidant enzyme activities, glutathione, malondialdehyde, and ceruloplasmin levels were significantly increased, whereas serum vitamin E, plasma vitamin C, and selenium levels were decreased in hyperthyroid patients compared to control subjects. The findings show that untreated toxic multinodular goiter causes profound alterations in components of the antioxidant system in erythrocytes indicative of increased oxidative stress. Taken together, these data suggest that hyperthyroid patients may benefit from dietary supplements of antioxidants. (C) 2001 Elsevier Science Inc.