Erythrocyte, plasma, and serum antioxidant activities in untreated toxic multinodular goiter patients

ALICIGÜZEL Y., Ozdem S., Ozdem S., KARAYALÇIN U., Siedlak S., Perry G., ...More

FREE RADICAL BIOLOGY AND MEDICINE, vol.30, no.6, pp.665-670, 2001 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 6
  • Publication Date: 2001
  • Doi Number: 10.1016/s0891-5849(00)00509-8
  • Journal Name: FREE RADICAL BIOLOGY AND MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.665-670
  • Keywords: antioxidant, erythrocyte, hyperthyroidism, plasma, serum, free radicals, VITAMIN-E STATUS, SUPEROXIDE-DISMUTASE, LIPID-PEROXIDATION, GLUTATHIONE-PEROXIDASE, THYROID-HORMONE, ANIMAL-TISSUES, SELENIUM, CATALASE, HYPERTHYROIDISM, AUTOXIDATION
  • Akdeniz University Affiliated: Yes

Abstract

Erythrocyte, plasma, and serum antioxidant activities were studied in patients with newly diagnosed and untreated toxic multinodular hyperthyroid goiter and compared to healthy control subjects. Erythrocyte antioxidant enzyme activities, glutathione, malondialdehyde, and ceruloplasmin levels were significantly increased, whereas serum vitamin E, plasma vitamin C, and selenium levels were decreased in hyperthyroid patients compared to control subjects. The findings show that untreated toxic multinodular goiter causes profound alterations in components of the antioxidant system in erythrocytes indicative of increased oxidative stress. Taken together, these data suggest that hyperthyroid patients may benefit from dietary supplements of antioxidants. (C) 2001 Elsevier Science Inc.