The value of XPD and XRCC1 genotype polymorphisms to predict clinical outcome in metastatic colorectal carcinoma patients with irinotecan-based regimens


Artac M., Bozcuk H., PEHLİVAN S., Akcan S., PEHLİVAN M., Sever T., ...More

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, vol.136, no.6, pp.803-809, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 136 Issue: 6
  • Publication Date: 2010
  • Doi Number: 10.1007/s00432-009-0720-3
  • Journal Name: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.803-809
  • Keywords: Colorectal cancer, Irinotecan, XPD, XRCC1, Single nucleotide polymorphisms, Overall survival, MULTIVARIATE-ANALYSIS, STRAND BREAKS, CANCER, CHEMOTHERAPY, GENE, REPAIR, CAPECITABINE, OXALIPLATIN, COMBINATION, TOXICITY
  • Akdeniz University Affiliated: Yes

Abstract

Previous studies have suggested that DNA repair enzyme polymorphisms may bear prognostic value in metastatic colorectal carcinoma (MCRC).