Akademik Veri Yönetim Sistemi
16th European Congress of Endocrinology 2014 3–7 May 2014, Wrocław, Poland, Wroclaw, Polonya, 3 - 07 Mayıs 2014, ss.35
Diffuse sclerosing variant of papillary thyroid carcinoma is a rare variant. It is
usually seen in children and young adults.The thyroid gland is diffusely involved.
It is characterized by scattered microscopic tumor islands, diffuse fibrosis,
calcification, abundant lymphocytic infiltration and psammom body when
compared with conventional papillary thyroid carcinoma. Usually the lesion
does not cause mass but rather a dominant nodule in one lobe is present in 50% of
cases. Lymph node metastasis is found in nearly all of the cases and distant
metastasis is often present.Although the prognosis is not good, it responds to
treatment.
Case
A 18-year-old female patient with Hashimoto’s thyroiditis applied to the Numune
State Hospital for enlargement in right thyroid gland. Thyroid ultrasound showed
nothing except roughness and heterogeneous appearance in the thyroid. The
patient was called to follow-up visits. As the patient felt further enlargement in the
thyroid, a repeat USG was performed which showed a heterogenous appearance
with microcalcifications. Thyroidal fine needle aspiration was done for exclusion
of thyroidal lymphoma. The smear showed hurthle cells having prominent
nucleoli and pleomorphic nuclei with highly atypical features on the ground of
chronic inflammatory cells. The cells were forming papillary structures in threedimensional pattern. Total thyroidectomy and cervical lymph node dissection was
done to the patient. She was reported as ‘Thyroidal papillary carcinoma, diffuse
sclerosing variant’ after pathological examination.
Discussion
Diffuse sclerosing variant is a rare variant of papillary thyroid carcinoma. It is
characterized histopathologically by psammom bodies, papillary structures
within lymphovascular structures, squamous metaplasia, stromal fibrosis and
dense lymphoid infiltration.
A 18-year-old female patient having a rare variant of papillary carcinoma who
applied with complaints of enlargement in thyroid and was diagnosed by blind
biopsy not from a nodule is discussed in this report.
DOI: 10.1530/endoabs.35.P112