The effect of cyclosporin A on cultured rabbit subconjunctival fibroblast proliferation

Bagci G., Yucel I., Duranoglu Y.

OPHTHALMOLOGICA, vol.213, no.2, pp.114-119, 1999 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 213 Issue: 2
  • Publication Date: 1999
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.114-119
  • Keywords: cyclosporin A, subconjunctival tissue, fibroblast proliferation, TOPICAL CYCLOSPORINE, T-CELLS, DISEASE, KERATOCONJUNCTIVITIS, PHARMACOLOGY, IMMUNOLOGY, LYMPHOKINE
  • Akdeniz University Affiliated: No


The aim of this study was to examine the possible effects of local application of a potent immunosuppressive drug, cyclosporin A (CsA), on fibroblast proliferation in vitro. Rabbit subconjunctival fibroblasts were cultured and incubated with varying doses of CsA (from 0.5 to 5%). Growth inhibition curves were obtained, and cell attachment and reversibility of drug-induced growth inhibition were studied. None of the doses stimulated fibroblast proliferation. CsA inhibited fibroblast proliferation depending on the dose and duration of application. Also, drug-induced growth inhibition decreased depending on dose and duration of application. While the dosage which led to 50% inhibition was found to be 7.2 mg/ml, 4% and higher doses had toxic effects.