Estradiol differentially regulates DUX4, beta-catenin and PAX3/PAX7 in primary myoblasts of facioscapulohumeral muscular dystrophy patients

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HANGÜL C., ÇELİK E. G., KAYA H., EROĞLU O., UYSAL H., KARAÜZÜM S.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.46, sa.4, ss.435-444, 2021 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 4
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1515/tjb-2020-0351
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, Food Science & Technology Abstracts, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.435-444
  • Anahtar Kelimeler: beta-catenin, DUX4, estradiol, facioscapulohumeral muscular dystrophy, FSHD, PAX3, PAX7, skeletal muscle, FSHD, D4Z4, EXPRESSION, ESTROGEN, REPEAT, PROGESTERONE, PREGNANCY, APOPTOSIS, LOCUS, WOMEN
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Objectives: There is a clinical variability and heterogeneity among Facioscapulohumeral Muscular Dystrophy (FSHD) patients. Escalation after menopause in women, early onset in men suggests that estrogen might be a protective factor on the course of FSHD. In spite of few molecular studies supporting the protective role of estrogen in FSHD in vitro, there is no study revealing the effect of estradiol on the protein levels of DUX4, beta-catenin and PAX3/PAX7. In present study, we investigated the effect of estradiol treatment on the expressions of DUX4, beta-catenin and PAX3/PAX7 protein levels.