Initial Results of Using Blood Beta 2 Transferrin as a Marker of the Functional Status of a Shunt

Ozdol C., Kulaksizoglu S., Uyar R., Gediz T., Aghayev K.

WORLD NEUROSURGERY, vol.128, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 128
  • Publication Date: 2019
  • Doi Number: 10.1016/j.wneu.2019.04.185
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Beta 2 transferrin, Diagnosis, Malfunction, Ventriculoperitoneal shunt, CEREBROSPINAL-FLUID, DIAGNOSIS
  • Akdeniz University Affiliated: Yes


OBJECTIVE: Ventriculoperitoneal shunt is the most common cerebrospinal fluid diversion procedure to treat hydrocephalus. With the change of physiologic cerebrospinal fluid absorption site from arachnoid granulations to the peritoneum, beta 2 transferrin enters the systemic circulation. Therefore, the detection of beta 2 transferrin in the blood can possibly be used as a noninvasive method to assess the functional status of the shunt. The objective of this study was to study the presence of beta 2 transferrin in patients with functional shunts and in shunts suspected of being malfunctional.