AKAP12/Gravin gene expression in colorectal cancer: clinical importance and review of the literature
JOURNAL OF BUON, vol.18, no.3, pp.635-640, 2013 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 18 Issue: 3
- Publication Date: 2013
- Journal Name: JOURNAL OF BUON
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.635-640
- Keywords: AKAP12/Gravin, anchoring proteins, carcinogenesis, colon cancer, immunohistochemistry, tumor suppressor gene, GRAVIN, IDENTIFICATION, ANGIOGENESIS, METHYLATION, CARCINOMA, LEUKEMIA, RECEPTOR, AKAP12, CDNA, SRC
- Akdeniz University Affiliated: Yes
Abstract
Purpose: : Colorectal cancer (CRC) is a common and potentially lethal disease. A number of genetic aberrations is known to take place in colorectal carcinogenesis, which leads to progressive alteration of normal mechanisms controlling cell growth. A-kinase-anchoring protein 12 (AKAP12) plays a role in cell proliferation, angiogenesis and cytoskeletal remodeling. The purpose of this study was to demonstrate the role of the AKAP12 gene expression in CRC patients and to determine its relationship (if any) with prognosis.