Interleukin-12 (-1188) A/C and interferon-gamma (+874) A/T gene polymorphisms in subacute sclerosing panencephalitis patients

OLGAÇ DÜNDAR N., Gencpinar P., Sallakci N., DUMAN Ö., HASPOLAT Ş., Anlar B., ...Daha Fazla

JOURNAL OF NEUROVIROLOGY, cilt.22, sa.5, ss.661-665, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 5
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1007/s13365-016-0442-7
  • Dergi Adı: JOURNAL OF NEUROVIROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.661-665
  • Anahtar Kelimeler: Subacute sclerosing panencephalitis, IL-12, IFN-gamma, SSPE, Gene polymorphism, CENTRAL-NERVOUS-SYSTEM, MEASLES-VIRUS, SSPE BRAIN, INFECTION, INDUCTION, DISEASE
  • Akdeniz Üniversitesi Adresli: Evet

Özet

The two polymorphisms [IL-12 (-1188) A/C and the IFN-gamma (+874) A/T)] are known to have functional consequences and henceforth were analyzed in subacute sclerosing panencephalitis (SSPE) patients to reveal a possible relation with these polymorphisms and this debilitating disease. For the IL-12 (-1188) A/C polymorphism, 78 patients and 90 healthy individuals were analyzed. An increase in the AA genotype was determined (p = 0.02, OR = 2.06). There was also a statistically significant difference between the control group and the patients with respect to the allele frequencies (p = 0.04, OR = 1.65). For the IFN-gamma (+874) A/T polymorphism, 69 SSPE patients and 115 controls were studied and there was not a significant difference between the two groups. Our findings suggested that not the IFN-gamma (+874) A/T but the IL-12 (-1188) A/C polymorphism is correlated with SSPE and having an AA genotype or A allele decreases the risk of developing SSPE by 2.06- and 1.65-fold, respectively.