Akademik Veri Yönetim Sistemi
REVUE DE MEDECINE VETERINAIRE, cilt.155, sa.11, ss.543-546, 2004 (SCI-Expanded)
To determine the effects of subconjunctivally injected flunixin meglumine (a nonsteroidal anti-inflammatory drug) and dexamethasone on matrix metalloproteinases (MMPs) in the tears of dogs with traumatic keratoconjunctivitis, six dogs with experimental keratoconjunctivitis were used. A 1 cm incision was made in the corneal epithelium. Tear samples from each dog were collected prior to and one week after surgery under sterile condition. The dogs (group 1) were treated with 1 mg /kg of subconjunctival flunixin meglumine (50 mg/mL)The dogs (group 2) were treated with 0.5 mg/kg of subconjunctival dexamethasone (8 mg/mL). Gelatine zymography was performed to determine enzyme activities in control and traumatic keratoconjunctivitis tear samples. Matrix metalloproteinases are present in tears of both normal and diseased eyes. All enzyme bands were totaly inhibited by dexamethasone and only active MMP-9 partially inhibited by flunixin meglumine. Effect of flunixin meglumine and dexamethasone give insight into the treatment procedure and pathogenesis of these diseases and may provide useful information for other species, particularly man.