Doxorubicin-induced testicular damage is related to PARP-1 signaling molecules in mice

Gungor-Ordueri N. E., KUŞCU N., TAŞATARGİL A., Burgucu D., Karacan M., ÇELİK ÖZENCİ Ç.

PHARMACOLOGICAL REPORTS, vol.71, no.4, pp.591-602, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 71 Issue: 4
  • Publication Date: 2019
  • Doi Number: 10.1016/j.pharep.2019.02.018
  • Journal Name: PHARMACOLOGICAL REPORTS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.591-602
  • Keywords: Doxorubicin, PARP-1, PJ34, Apoptosis, Testicular damage, Male infertility, DIABETIC ENDOTHELIAL DYSFUNCTION, INDUCED OXIDATIVE STRESS, ADP-RIBOSE POLYMERASE, POLY(ADP-RIBOSE) POLYMERASE, PHARMACOLOGICAL INHIBITION, CYTOCHROME-C, CELL-DEATH, APOPTOSIS, SYNTHETASE, PROTECTION
  • Akdeniz University Affiliated: Yes

Abstract

Background: Doxorubicin (DOX), is a chemotherapeutic agent, which evokes oxidative stress and cell apoptosis in testicular tissue. It is known that the activation of the nuclear enzyme poly (ADP-ribose) polymerase (PARP), leading to apoptosis induced by DOX. The aim of the present study is to investigate whether PARP pathway has a role in DOX-induced testicular damage and infertility utilizing pharmacological PARP-1 inhibitor, PJ34, and PARP-1 knockout mice model.