Changes of HMGB-1 and sTLR4 levels in cerebrospinal fluid of patients with febrile seizures

Kaya M. A., ERİN N., Bozkurt O., ERKEK N., DUMAN Ö., HASPOLAT Ş.

EPILEPSY RESEARCH, cilt.169, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 169
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.eplepsyres.2020.106516
  • Dergi Adı: EPILEPSY RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Abstracts in Social Gerontology, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: Febrile convulsion, HMGB-1, sTLR4, Cerebrospinal fluid (CSF), MOBILITY GROUP BOX-1, RECEPTOR 4
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Purpose: Fever-induced inflammatory processes and pro-inflammatory cytokines have gained importance in recent years in the pathogenesis of febrile convulsion. Increased levels of HMGB1 (high mobility group box 1), one of the most important pro-inflammatory cytokines, are associated with prolongation of seizure duration, recurrence of seizures and the development of epilepsy. Changes in the sTLR4 level (soluble toll-like receptor 4) in the cerebrospinal fluid (CSF) are thought to be associated with memory and learning functions. In our study, we aimed to evaluate changes in HMGB1 and sTLR4 levels in patients who had febrile seizures between 6 months and 6 years.