Akademik Veri Yönetim Sistemi
Pharmaceutical Chemistry Journal, 2025 (SCI-Expanded, Scopus)
Several different types of natural remedies are employed within the realm of supplemental medicine. The most valuable of these natural resources are plants. Thymus vulgaris L. was gathered in Mangesh/Duhok (Iraq) and its antioxidant, antimicrobial, antiproliferative, and DNA-protective properties were evaluated. Moreover, chemical and phenolic substances were detected. In this context, a Soxhlet apparatus was used to extract the plant’s above-ground portions with methanol and dichloromethane. The DPPH assay and Rel Assay kits were used to measure the antioxidant activity of the samples. The agar dilution test was used to evaluate the antimicrobial activity. The pBR322 supercoiled DNAwas utilized to evaluate DNA-protective properties. The MTT assay revealed antiproliferative efficacy against the A549 cancer-cell line. The GC-MS instrument was used to analyze their chemical makeup. On the HPLC, phenolic levels were calculated. The research showed that the plant has potent DNA-protective and antiproliferative properties. Furthermore, it was shown that the plant extract in MeOH had significant DPPH activity. At doses between 200 and 800 g/mL, the plant extracts were found to be active against several bacterial and fungal species. The plant’s total antioxidant status was 3.549 ± 0.085 mmol/L, total oxidant status was 2.780 ± 0.129 mol/L, and oxidative stress index was 0.078 ± 0.002. As a consequence of phenolic analysis, we know that there is gallic acid, catechin, and cinnamic acid present. Moreover, the GC-MS examination uncovered nine unique compounds. T. vulgaris was shown to have significant biological activity.