Role of a second transplantation for children with acute leukemia following posttransplantation relapse: a study by the Turkish Bone Marrow Transplantation Study Group

Hazar V., Karasu G. T., Uygun V., Ozbek N., KARAKÜKCÜ M., Ozturk G., ...Daha Fazla

LEUKEMIA & LYMPHOMA, cilt.61, sa.6, ss.1465-1474, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 61 Sayı: 6
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1080/10428194.2020.1716220
  • Dergi Adı: LEUKEMIA & LYMPHOMA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.1465-1474
  • Anahtar Kelimeler: Posttransplantation relapse, second transplantation, acute leukemia, children, STEM-CELL TRANSPLANTATION, ALLOGENEIC HEMATOPOIETIC SCT, ACUTE MYELOID-LEUKEMIA, HEMATOLOGIC MALIGNANCIES, SURVIVAL, MULTICENTER, ADOLESCENTS, BLOOD
  • Akdeniz Üniversitesi Adresli: Evet

Özet

We examined outcomes of 51 pediatric patients with relapsed acute leukemia (AL) who underwent a second allogeneic hematopoietic stem cell transplantation (alloHSCT). After a median follow-up of 941 days (range, 69-2842 days), leukemia-free survival (LFS) and overall survival (OS) at 3 years were 26.6% and 25.6%, respectively. The nonrelapse mortality rate (NMR) and cumulative incidence of relapse (CIR) were 36.4% and 42.4%, respectively. The Cox regression analysis demonstrated that the risk factors at second transplantation for predicting limited LFS were active disease (hazard ratio (HR) = 5.1), reduced intensity conditioning (RIC) (HR = 5.0), matched unrelated donor (MUD) (HR = 3.4) and performance score <80 (HR = 3.2). Pediatric patients with AL who relapsed after their first alloHSCT may survive with a second alloHSCT. Disease status, conditioning intensity, donor type, and performance score at the second transplantation are the relevant risk factors. A score based on these factors may predict the results of the second transplantation.