Akademik Veri Yönetim Sistemi
Psychiatry Research, cilt.353, 2025 (SCI-Expanded)
Objective: Opioid Use Disorder (OUD), has been shown to have chronic nature that course with relapses and remissions. People with OUD remain at risk for recurrence for years even after an initial remission was achieved. Thus we designed a study of regular outpatients admitting to monthly follow-up process after the inpatient detoxification program which might give additional details about when the relapse risk significantly rises. Methods: The study is based on a prospective study with a sample of 196 patients with OUD. 167 patients were considered for the study. Patients were assessed with clinical scales at baseline evaluation and were followed-up regularly at every month following the inpatient treatment program. Upon completion of the detoxification period with buprenorphine–naloxone (BN), patients choosing to continue treatment were followed with either BN maintenance or injectable nalmefene, according to shared decision-making. Survival analyses were conducted to compare the time of treatment retention and abstinence in bivariate and multivariate levels. Results: 36.5 % of patients attended follow-up in the first month, this rate declined to 22.2 % by the sixth month and to 9.6 % by the twelfth month. Participants with low-income, lack of previous OUD treatment, having substance-induced psychosis, daily opioid use, emotional neglect, physical childhood traumas had significantly less duration of treatment adherence, whereas those with low-income, daily opioid use, lack of BN use history, inadherent to inpatient treatment program, physical neglect and high dissociation scores were associated with less duration of abstinence. Longer time of abstinence was independently associated with previous BN use, retention of inpatient program, less severe craving scores and non-daily opioid use in the multivariate model. Conclusions: This work contributes to the findings in the literature and helps elucidating the effect of psychopathologies on relapse. Identifying the treatment needs of patients with risky clinical characteristics must be resumed with tailored treatments in order to prevent relapse of patients with OUD.