Changes in expressions of ADAM9, 10, and 17 as well as alpha-secretase activity in renal cell carcinoma
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, cilt.35, sa.1, 2017 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 35 Sayı: 1
- Basım Tarihi: 2017
- Doi Numarası: 10.1016/j.urolonc.2016.08.010
- Dergi Adı: UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Anahtar Kelimeler: alpha-Secretase, ADAM10, ADAM9, ADAM17, Renal cell carcinoma, Human, PANCREATIC DUCTAL ADENOCARCINOMA, AMYLOID PRECURSOR PROTEIN, MESSENGER-RNA EXPRESSION, CONVERTING-ENZYME, GROWTH-FACTOR, GENE-EXPRESSION, BREAST-CANCER, TUMOR-SUPPRESSOR, FACTOR-RECEPTOR, UP-REGULATION
- Akdeniz Üniversitesi Adresli: Evet
Özet
Background: ADAM9, 10, and 17 are a class of disintegrins and metallproteinases with oc-secretase activity. There are conflicting results regarding the role(s) of ADAM9, 10, and 17 in carcinogenesis, and only a few studies have examined their levels and cellular localization in renal cell carcinoma (RCC). Studies examining changes in oc-secretase activity in RCC compared to enzymatic activity of the uninvolved kidney are lacking.