Effect of sulfur dioxide inhalation on erythrocyte antioxidant status and lipid peroxidation in experimental diabetes

Agar A., Kucukatay V., Yargicoglu P., Bilmen S., Gumuslu S., Yucel G.

DIABETES & METABOLISM, vol.26, no.2, pp.140-144, 2000 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 2
  • Publication Date: 2000
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.140-144
  • Keywords: SO2, diabetes, antioxidant enzymes, TBARS, rat, erythrocyte, SUPEROXIDE-DISMUTASE, METABOLISM, MELLITUS
  • Akdeniz University Affiliated: Yes


The effect of sulfur dioxide (SO2) on red cell antioxidant status and lipid peroxidation was examined in this research. Forty healthy male albino rats, aged three months, were divided into four equal groups: Control (C), SO2+C (CSO2), diabetic (D) and SO2+D (DSO2). Experimental diabetes mellitus was induced by i.v injection of alloxan with a dose of 50 mg/kg body weight. Ten ppm SO2 was administered to the animals of SO2 exposed groups in an exposure chamber for one hr/day x 7 days/wk x 6wks while other groups were exposed to filtered air in the same condition. SO2 exposure, while markedly decreasing Cu, Zn-Superoxide dismutase (Cu, Zn-SOD) activity, significantly increased glutathione peroxidase (GSH-Px), catalase (CAT), glutathione (GSH) and glutathione-s-transferase (GST) activities and TEARS values in CSO2 and DSO2 groups compared with their respective control groups. From these results, it could be concluded that adaptative changes occurred in antioxidant systems that may counteract the free radical effect of SO2 in the experimental groups.